Rainsford K.D. Ibuprofen: Pharmacology, Therapeutics and Side Effects

Springer, 2012. — 259 p. — ISBN: 978-3034804950.Качество: Изначально компьютерное (eBook).
This well-written book reviews the pharmacology, clinical uses and the various adverse effects of Ibuprofen, the disposition and unique modes of action in relation to clinical effects of the drug as well as various formulations. The use of combinations with other drugs (e.g. paracetamol, codeine, caffeine) are critically assessed and the impact of natural products and Chinese Medicines on the safety of ibuprofen.Background
Introduction of Ibuprofen for Non-Prescription (OTC) Use
Experience at Prescription Level Dosage
Scope and Objectives
Biodisposition in Relation to Actions
Key Aspects of the Pharmacokinetics and Biodisposition
of Ibuprofen
Impact of Variability in Pharmacokinetics
Plasma/Serum Concentrations Relevant to Onset
of Analgesia
Dental Pain Model
Induced Pain Models
Applicability to Other Acute Pain States
Antipyresis
Therapeutically-Relevant Concentrations
in Rheumatic Diseases
Plasma/Serum Levels in Arthritic Diseases
Accumulation in Synovial Fluids
Rectal Administration in Adults and Children
Pharmacokinetics in Children
Juvenile Idiopathic (Rheumatoid) Arthritis
Cystic Fibrosis
Patent Ductus Arteriosus
Mechanisms of Inflammation and Sites of Action of NSAIDs
Pathways of Inflammation
Link of Pharmacokinetics to Pharmacodynamics.
Relation of Analgesic Effects to COX-1
and COX-2 Inhibition
xiii3.4 Multiple Modes of Anti-inflammatory Activities
Pain Control Pathways
Antipyretic Activity...
Clinical Efficacy
Dental Pain
Pain Relief at OTC Dosages
Treatment of Pain in Osteoarthritis and Related
Conditions.
Paediatric Uses
Acute Fever in Children
Juvenile Idiopathic (Rheumatoid) Arthritis
Drug Derivatives and Formulations
Dexibuprofen
Combinations with Caffeine
Ibuprofen–Codeine Combinations
Ibuprofen–Paracetamol Combination
Amino Acid and Salt Formulations
Topical Formulations
General Safety ProfilePharmacokinetic Aspects of Importance
in the Safety of Ibuprofen
Pharmacokinetic Variations
Pharmacokinetics in Oriental Compared with Caucasian
Populations
Influence of Disease States on PK of Ibuprofen
ADRs and Safety in Prescription-Level Doses
Epidemiological Studies
Outcomes from Large-scale Clinical Trials
Adverse Events Attributed to Ibuprofen at Non-prescription
(OTC) Dosages
ADR Risks in Oriental Populations
Potential Concerns with Chinese Traditional and Herbal
Medicines
Adverse Events and Safety in Paediatric Populations
Gastro-Intestinal Toxicity
Epidemiological Studies
GI Risks in Coxib Studies at Prescription Doses
GI Symptomatic Adverse Reactions
GI Events at OTC Dosages
Reducing GI Risks.
Disease-related Issues
Heightened Concerns from the Coxib Studies
Epidemiological Studies
Recent Clinical Trials and Meta-Analyses
Individual Trials
Interaction of Ibuprofen with the Anti-platelet
Effects of Aspirin
Effects in Hypertension
Congestive Heart Failure and Cardio-Renal Effects
Balancing CV and GI Risks of NSAIDs
Renal Toxicity
Hepatic Toxicity
Other Adverse Reactions
Hypersensitivity Reactions and Asthma
Cutaneous Reactions
Risk of Fractures.
Global Assessment of Adverse Reactions and Human
Toxicology
Initial Basis for Approval for OTC Sale in UK and USA
Experience in the UK
Cases of Poisoning in UK
Concerns About Misuse of Analgesics in USA
Overall Assessment
Benefit/Risk Analysis
Assessment of Risks and Procedures for Their Reduction
Examples of Advice for Ibuprofen Packages and PILs