Came P.E., Carter W.A. (eds.) Interferons and Their Applications

Springer, 1984. — 575 p. — (Handbook of Experimental Pharmacology, Vol. 71).Interferons and Their Applications: Past, Present, and Future (M. Krim)Interferon Research: The Beginnings
The Current Windfall in Interferon Research.
Clinical Applications
Looking Ahead
Future Prospects
Possible Socioethical Problems.Assay of Interferons. (S. E. Grossberg, P. M. Jameson, and J. J. Sedmak)Bioassays
Data Analysis, Unitage, and Standardization.
Interferon Standards
RadioimmunoassaysEvolution of Interferon Genes. (D. Gillespm, E. Pequignot, and W. A. Carter)Coding Region Nucleotide Sequence
3' Noncoding Region Nucleotide Sequence.
Structural Evolution of the 3' Noncoding Region.
Coding Region Amino Acid Sequence.
Concluding RemarksComparative Analysis of Interferon Structural Genes (P. B. Seghal and A. D. Sagar)Molecular Cloning of Some Human IFN-(X cDNA and Chromosomal Genes
Molecular Cloning of a Human IFN-fJ cDNA and Its Chromosomal Gene
Comparative Structure of Some IFN-(X and -fJ mRNAs and Proteins Deduced from cDNA Clones
Comparative Structure of Some IFN-a and -PI Chromosomal Genes
Other Human IFN-IX and -P Genes
Chromosomal Localization
IFN Structural Genes in Other Species
ConclusionsComparative Structures of Mammalian Interferons (K. C. Zoon and R. Wetzel.)Purification and Characterization of Native Interferons
Purification and Characterization of rONA-Derived Interferons
Protein Structure and Interferon Activity
Structure PredictionRegulatory Control of Interferon Synthesis and Action (H. Smith-Johannsen, Y-T. Hou, X-Yo Liu, and Y. H. Tan)
Regulatory Control of IFN Synthesis
Regulatory Control of IFN ActionApplication of Recombinant DNA Technology to Expression of Human Interferon Genes (S. Panem)General Comments on the Experimental Strategies for Cloning IFNs
Comments on Strategies for IFN Production in rDNA Hosts.
Examples of Findings Directly Derived from Cloning ExperimentsThe Molecular Mediators of Interferon Action (C. Baglioni)The Inhibition of Protein Synthesis by Double-Stranded RNA
2',5'-Oligo(A)
Degradation of Viral RNA in Infected Cells
Other Antiviral Mechanisms
ConclusionsThe Cellular Effects of Interferon (J. L. Taylor, J. L. Sabran, and S. E. Grossberg)Cell Growth Inhibition by IFN
Effects of IFN on Cell Cycle.
Other Cellular Effects of IFN
Effects of IFN on Cellular Differentiation
Conclusions and EpilogueInterferon Induction by Viruses. (P. I. Marcus)
Introduction and Perspective
A Quantitative Approach to Interferon Induction by Viruses: Defining the Interferon-Inducing Particle
Dose (Multiplicity)-Response (Interferon Yield) Curves for Interferon
Induction/production
dsRNA as the Interferon Inducer Moiety of Viruses: One Molecule as the
Threshold for Induction
One Molecule of dsRNA as the Interferon Inducer Moiety of Different
VirusesInterferon Induction by Nucleic Acids: Structure-Activity Relationships (P. F. Torrence and E. de Clercq)
General Considerations
Nucleic Acid Strandedness and Its Consequences for Interferon Induction
The Effectiveness of a Nucleic Acid Complex as an Interferon Inducer
Depends on the Molecular Size of the Complex and/or Its Constituent
Homopolymer Strands
Interferon Induction by Synthetic Polynucleotides Depends on the
Structure of the Nucleotide Building Block
Role of Polynucleotide Conformation in the Interferon Induction Process
The Spectrum of Biologic Activity of Exogenous Nucleic AcidsProduction and Characterization of Human Leukocyte Interferon (N. O. Hill.)Production
Purification
Characterization
DiscussionLymphoblastoid Interferon: Production and Characterization (N. B. Finter and K. H. Fantes)Spontaneous Formation of Interferon by Lymphoblastoid Cells
Interferon Formed by Lymphoblastoid Cells After Induction.
Interferons Made by Namalwa CellsFibroblast Interferons: Production and Characterization. (V. G. Edy)
A. Introduction
B. Production
C. Characterization of Fibroblast InterferonsImmune Interferon. (J. A. Georgiades, S. Baron, W. R. Fleischmann, Jr.,
M. Langford, D. A. Weigent, and G. J. Stanton)
Position of Human Immune Interferon in the Lymphokine System
Production of HuIFN-y
Properties of IFN-y
Purification of IFN-y
Characterization of IFN-y Induced by Staphylococcal Enterotoxin A
The Prospect of Using IFN for Treatment of Viral and NeoplasticComparative Biologic Activities of Human Interferons (P. K. Weck and P. E. CameNative Interferons: Cell Source.
Biologic Activity
Recombinant DNA-Derived Interferons.
ConclusionsManufacture and Safety of Interferons in Clinical Research (J. C. Petricciani, E. C. Esber, H. E. Hopps, and A. Aitallah)Manufacture
SafetyNonpolynucleotide Inducers of Interferon. (D. A. Stringfellow)Chemical Structures
Comparative Interferon, Antiviral, and Antitumor Activity.
Hyporeactivity.Agents Which Modulate the Activity of Interferon (D. R. Strayer and W. A. Carter)Antineoplastic Agents
Antiviral Agentsoside
Ganglioside-Binding Agents
Hormones
Growth Factors
Prostaglandins
Vitamins
Vitamin A
Vitamin C
Histamine Antagonists
Differentiation-Promoting Agents: DMSO, TPA, Insulin.Effects of Interferon and Its Inducers on Leukocytes and Their Immunologic Functions. (J. M. Zarling)Effects of Interferon and Its Inducers on Antibody Production
Effects of Interferon on Cell Surface Antigen Expression on Lymphoid Cells
Effects of Interferon on Mitogen- or Antigen-Induced Lymphocyte Proliferative and Cytotoxic Responses
Effects of Interferon on Delayed-Type Hypersensitivity Responses
Effects of Interferon and Its Inducers on Macrophage Functions
Effects of Interferon and Its Inducers on Natural Killer Cell Activity
Summary and Concluding CommentsClinical Use of Interferons: Localized Application in Viral Diseases (S. B. Greenberg and M. W. Harmon)Respiratory Virus Infections
Ocular Virus Infections
Miscellaneous Virus InfectionsClinical Use of Interferons: Systemic Administration in Viral Diseases (J. A. Armstrong)Herpesviruses
Hepatitis B Virus Infection
Other Virus Infections
Pharmacokinetics and Toxicology of Systemically Administered InterferonClinical Use of Interferons: Central Nervous System Disorders (A. M. Salazar, C. J. Gibbs, JR., D. C. Gajdusek, and R. A. Smith)Pharmacology.
Clinical Use
ConclusionsClinical Investigation of Interferons: Status Summary and Prospects for the Future. (J. U. Gutterman)Leukocyte Interferon (lFN-a)
Fibroblast Interferon (IFN-P)
Recombinant DNA-Derived Interferon
General Comments About Studies to Date and Future Directions.Utilization of Stabilized Forms of Polynucleotides (H. B. Levy and F. L. Riley)Thiolated Derivatives
DEAE-Dextran
Liposomes
Stabilization with Polylysine
PICLC in Monkeys
Importance of Size of Components of PICLC
Antiviral Studies in Monkeys
Adjuvant Actions
Studies in Humans
Comparison of Interferon Inducers with Exogenous InterferonTherapeutic Applications of Double-Stranded RNAs (J. J. Greene, P. O. P. Ts'o, D. R. Strayer, and W. A. Carter)Spectrum of Actions Produced by dsRNA
Poly(I)· poly(C): Antiviral and Antitumor Activities and Toxicity
Modulating the Spectrum of Activities Triggered by dsRNA
Poly(I)· poly(C12U): An Interferon Inducer with Few Toxic Responses
ConclusionsMonoclonal Antibodies to Interferons (D. C. Burke and D. S. Secher)
Introduction: The Preparation and Use of Monoclonal Antibodies
Conventional Antibodies to Interferon
NK2: A Monoclonal Antibody to Human Interferon-IX
Subject Index.