Steinhoff G. (Ed.) Regenerative Medicine - from Protocol to Patient

2nd Edition. — Springer Science+Business Media, Dordrecht, 2013. — 211 p. — ISBN: 978-94-007-5689-2Regenerative Medicine is a fast emerging interdisciplinary field of research and clinical therapies on the repair, replacement or regeneration of cells, tissues or organs in congenital or acquired disease. This new field of research and clinical development focussing on stem cell science and regenerative biology is just starting to be the most fascinating and controversial medical development at the dawn of the twenty-first century. It can be envisaged that this development will establish completely new molecular and cellular techniques for medical therapy. An early rush of scientific development was set up more than 100 years ago by the physiology of blood regeneration (Hall and Eubanks 1896) and successful vascular surgical techniques for organ transplantation (Carrel and Guthrie 1905). However, the clinical realization of allogenic blood transfusion lasted until the discovery of the blood group antigens (Landsteiner and Levine 1928) and successful routine allogenic organ and bone marrow transplantation even until the end of the last century.
Similar to the field of allogenic cell and organ transplantation, it seems that Regenerative Medicine again condenses mankind’s visions, hopes, and fears regarding medicine: Hopes of eternal life and effective treatment of uncurable disease as well as fears of misuse of technology and uncontrolled modifications of life are polarizing the scienti fi c field. The development and public acceptance of new ethical and regulatory guidelines is a necessary process to support the further clinical development. Nevertheless, the vision of a new medicine using the regenerative power of biology to treat disease and restructure the organism is setting the aim for scientific, technological and medical development. Viewing the great expectations to restructure and regenerate tissue, organs or organisms the current attempts of scientist and physicians are still in an early phase of development.
The field of Regenerative Medicine has developed rapidly over the last 20 years with the advent of molecular and cellular techniques. This textbook on “Regenerative Medicine: From Protocol to Patient” is aiming to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases. The international leading experts from four continents describe the latest scientific and clinical knowledge of the field of Regenerative Medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. Patient needs are advocated by the proposition initiatives on the scientific development of new therapies.
This textbook is organized into five major parts: (I) Biology of Tissue Regeneration, (II) Stem Cell Science and Technology, (III) Tissue Engineering , Biomaterials and Nanotechnology, (IV) Regenerative Therapies , and (V) Regulation and Ethics.History of Regenerative Medicine
Biology of Tissue Regeneration
Extracellular Matrix and Tissue Regeneration
Stem Cell Niche
Stem Cells and Asymmetric Cell Division
Stem Cells in the Developing and Adult Nervous System
Stem Cell Science and Technology
Characterization and Classi fi cation of Stem Cells
Human Embryonic Stem Cells
Induced Pluripotent Stem Cells
Spermatogonial Stem Cells
Hematopoietic Stem Cells
Cardiovascular Stem Cells
Neural Stem Cells
Liver Stem Cells
Gastro Intestinal Stem Cells
Cancer Stem Cells
Mesenchymal Stem Cells – An Oversimpli fied Nomenclature for Extremely Heterogeneous Progenitors
Musculoskeletal Stem Cells
Tissue Engineering, Biomaterials and Nanotechnology
When Stemness Meets Engineering: Towards “Niche” Control of Stem Cell Functions for Enhanced Cardiovascular Regeneration
Vector Technology and Cell Targeting: Peptide-Tagged Adenoviral Vectors as a Powerful Tool
for Cell Specific Targeting
Regenerative Chimerism Bioengineered Through Stem Cell Reprogramming
Biodegradable Materials
Biomaterials-Enabled Regenerative Medicine in Corneal Applications
Functionalized Nanomaterials
Biointerface Technology
Regenerative Therapies
Emerging Concepts in Myocardial Pharmacoregeneration
Blood
Regenerative Medicine in the Central Nervous System: Stem Cell-Based Cell- and Gene-Therapy
Regenerative Therapy for Central Nervous System Trauma
Regenerative Therapies for the Ocular Surface
Lacrimal Gland Regeneration: Progress and Promise
The Development of a Stem Cell Therapy for Deafness
Oral and Maxillo-facial
Regenerative Therapies-Trachea
Lung
Vascular Regeneration: Endothelial Progenitor Cell Therapy for Ischemic Diseases
Heart
Liver
Kidney
Gastrointestinal Tract and Endocrine System
Preclinical Animal Models for Segmental Bone Defect Research and Tissue Engineering
Constraints to Articular Cartilage Regeneration
Muscle and Ligament Regeneration
Skin
Regulation and Ethics
Regulatory Frameworks for Cell and Tissue Based Therapies in Europe and the USA
Ethics and Law in Regenerative Medicine: A Legal and Ethical Outline on Regenerative Medicine in Research in France, Germany and Poland