Rostovtseva T.K. (ed.) Molecular Basis for Mitochondrial Signaling

Springer International Publishing AG, 2017. — 388 p. — (Biological and Medical Physics, Biomedical Engineering). — ISBN: 3319555375.This book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mitochondria. A wide array of cuttingedge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mitochondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mitochondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. Molecular Basis for Mitochondrial Signaling covers these and many more recent studies of mitochondria function, their communication with other organelles, and their critical roles in development, aging, and in a plethora of stressful or degenerative events. Authored by leading researchers in the field, this volume will be an indispensable reference resource for graduate students and academics working in related areas of biophysics and cell biology as well as for professionals within industry.Mitochondrial Calcium Signaling
Mitochondrial Ca2+ Handling and Behind: The Importance of Being in Contact with Other Organelles
Molecular Players of Mitochondrial Calcium Signaling: Similarities and Different Aspects in Various Organisms
The Mitochondrial Permeability Transition Pore: Structure and Function
The Mitochondrial Permeability Transition Pore: Molecular Structure and Function in Health and Disease
Mitochondrial Calcium Uptake in Activation of the Permeability Transition Pore and Cell Death
Mitochondrial Outer Membrane Transport Systems: Structure, Function, and Physiological Implications
Voltage-Dependent Anion Channels and Tubulin: Bioenergetic Controllers in Cancer Cells
An Assessment of How VDAC Structures Have Impacted Our Understanding of Their Function
Plant VDAC Permeability: Molecular Basis and Role in Oxidative Stress
Lipids in Regulation of the Mitochondrial Outer Membrane Permeability, Bioenergetics, and Metabolism
The Mitochondrial Outer Membrane Potential as an Electrical Feedback Control of Cell Energy Metabolism
Mitochondria and Cellular Signaling Network
New Insights on the Regulation of Programmed Cell Death by Bcl-2 Family Proteins at the Mitochondria: Physiological and Pathophysiological Implications
The 18 kDa Translocator Protein (TSPO): Cholesterol Trafficking and the Biology of a Prognostic and Therapeutic Mitochondrial Target
Protein Import Channels in the Crossroads of Mitochondrial Function
Substrate Selection and Its Impact on Mitochondrial Respiration and Redox