Lee D.S. (Ed.) Radionanomedicine: Combined Nuclear and Nanomedicine

Springer, 2018. — 456 p. — (Biological and Medical Physics, Biomedical Engineering). — ISBN: 3319677195.This book describes radionanomedicine as an integrated medicine using exogenous and endogenous This book describes radionanomedicine as an integrated approach that uses exogenous and endogenous nanomaterials for in vivo and human applications. It comprehensively explains radionanomedicine comprising nuclear and nanomedicine, demonstrating that it is more than radionanodrugs and that radionanomedicine also takes advantage of nuclear medicine using trace technology, in which miniscule amounts of materials and tracer kinetic elucidate in vivo biodistribution.
It also discusses exogenous nanomaterials such as inorganic silica, iron oxide, upconversion nanoparticles and quantum dots or organic liposomes labelled with radioisotopes, and radionanomaterials used for targeted delivery and imaging for theranostic purposes. Further, it examines endogenous nanomaterials i.e. extracellular vesicles labelled with radioisotopes, known as radiolabelled extracellular vesicles, as well as positron emission tomography (PET) and single photon emission computed tomography (SPECT), which elucidate the biodistribution and potential for therapeutic success.Exogenous Radionanomedicine: Inorganic Nanomaterials
Porphyrin and Phthalocyanine Radiolabeling
Graphene-Based Nanomaterials
Organic Nanomaterials: Liposomes, Albumin, Dendrimer, Polymeric Nanoparticles
Endogenous Radionanomedicine: Extracellular Vesicles
Endogenous Radionanomedicine: Radiolabeling
Endogenous Radionanomedicine: Biodistribution and Imaging
Endogenous Radionanomedicine: Validation of Therapeutic Potential
Surface Modification of Radionanomedicine
Radiolabeling Method: Core/Surface Labeling, Chemical and Physical Labeling
Click Chemistry for Radionanomedicine Platform
Preservation of Ligand Functionality by Click Chemistry
Bioorthogonal Reaction for Fluorine-18 Labeling
Preclinical PET and SPECT for Radionanomedicine
Tracer Kinetics in Radionanomedicine
Size-, Shape- and Charge-Dependent Pharmacokinetics of Radiolabeled Nanoparticles
Polyethylene Glycolation (PEGylation) and the Similar
Excretion and Clearance
Immune Response to PEGylated Nanomedicines: Impact of IgM Response
Innate Immunity to Nanomaterials
Molecular Imaging Using Radionanomedicine
Therapeutic/Theranostic Use of Radionanomedicine