Zinkernagel Martin, Dysli Chantal (eds.) Fluorescence Lifetime Imaging Ophthalmoscopy

Springer, 2019. — 123 p. — ISBN: 978-3-030-22877-4This book focuses on the emerging non-invasive imaging technique of Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO). FLIO reveals unique information on retinal diseases, ranging from age-related macular degeneration and vascular diseases to hereditary retinal dystrophies. Fluorescence lifetimes enable the evaluation of disease progression before irreversible structural changes occur. The image acquisition is suitable for diagnostic purposes and follow-up examinations to investigate the natural course of disease, and to monitor the effects of possible therapies.This book fills the gap between available literature and gives state-of-the-art guidance on the principles of the FLIO technique, image acquisition, and data analysis. Written by a team of expert leaders within this field, this book will be relevant for scientists and clinicians with an interest in ophthalmoscopy.FLIO Technique and Principles
FLIO Historical Background
Fluorescence Lifetime Imaging Microscopy
The Fluorescence Lifetime Imaging Ophthalmoscope
Image Acquisition and Analysis
Fluorophores in the Eye
FLIO in the Healthy Eye
FLIO in Retinal Diseases
Age-Related Macular Degeneration
FLIO in Diabetic Retinopathy
Retinal Artery Occlusion
Central Serous Chorioretinopathy
Macular Telangiectasia Type 2
Hereditary Retinal Diseases: Stargardt, Choroideremia, Retinitis Pigmentosa
Macular Pigment
Fluorescence Lifetime Imaging Ophthalmoscopy in Alzheimer’s Disease
FLIO in Mouse Models
Discussion and Summary