Jian-Ying Wang, Casero R.A.Jr. (eds.) Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research

New York: Humana Press, 2006. — 485 p.Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research presents current state-of-the-art findings relevant to cellular and molecular functions of polyamines, as well as providing the underlying conceptual basis and knowledge regarding potential therapeutic-targeting polyamines and polyamine metabolism leading to the development of new therapeutic approaches for cancers and other diseases. Divided into four main parts that include polyamines in signal transduction of cell proliferation; polyamines in cellular signaling of apoptosis, carcinogenesis, and cancer therapy; polyamines in cell motility and cell-cell interactions; and polyamine homeostasis and transport, these topics are addressed by internationally recognized experts in their respective fields.
This timely guide provides the whole picture of polyamines-past, present, and potential future, and offers a wealth of information regarding basic knowledge and current progress on cellular functions of polyamines and their potential clinical applications in cancer therapy. For investigators in the fields of polyamines, physiology, pharmacology, and cancer research, Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research serves as a foundation based on research and addresses the potential for subsequent applications in clinical practice.Front Matter
Front Matter
Polyamine Structure and Synthetic Analogs
Acute Increases in Intracellular Putrescine Lead to the Increase in Steady-State Levels of c-fos, c-jun, RING3 , and Id-1 mRNAs
Polyamine-Dependent Early Cellular Signals and Cell Proliferation
Cellular Signals Mediating Growth Arrest After Polyamine Depletion
Role of Polyamines in the Regulation of Chromatin Acetylation
Role of Polyamines in Regulation of Sequence-Specific DNA Binding Activity
Polyamine Metabolism and the Hypertrophic Heart
Influence of Polyamines on Breast Cancer Biology
Polyamines in Regulation of Prostatic Cell Growth
Polyamines in Kidney Biology
Polyamines in Pulmonary Vascular Biology
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Recent Advances in the Understanding of Mammalian Polyamine Catabolism
Cellular Signaling and Polyamines in the Control of Apoptosis in Intestinal Epithelial Cells
The Role of Ornithine Decarboxylase in Myc-Induced Tumorigenesis
Protective Effect of Polyamines on NSAID-Induced Injury and Apoptosis
Role of Polyamines in the Control of the Immune Response in the Brain
Implication of Polyamines in Apoptosis of Immunoresponse Cells
Polyamines and Cancer
Polyamine Pools and Cancer Prevention
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Polyamines and Cytoskeletal Regulation During Intestinal Epithelial Restitution
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Regulation of Kv Channel Activity and Intercellular Junctions by Polyamines in Intestinal Epithelial Cells
Polyamine Block of Kir Channels
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Regulation of Ornithine Decarboxylase Expression
Evidence for a Multistep Model for Eukaryotic Polyamine Transport
Bacterial and Eukaryotic Transport Systems
Regulation of S-Adenosylmethionine Decarboxylase
Genetic Engineering of Polyamine Catabolism in Transgenic Mice and Rats
Back Matter