Makovitzky J. et al. Analysis of Amyloid Using Various Methods

Springer, 2025. — 309 p. — ISBN-13 978-3031707148This book explores the world of amyloid, consisting of heterogeneous deposits that have captivated scientists for decades. Amyloid, characterized by its highly organized insoluble protein fibrils exhibiting cross-layered quaternary beta-sheet structures, comprises diverse components such as the P-component, sialic acid, O-acyl sialic acid, and sGAG components. This assembly forms an anisotropic entity that induces birefringence in linearly polarized light, creating a distinctive optical signature.
Initially linked to human disease and tissue damage, the predominant idea that amyloid only harms the host has been challenged. Recent pioneering studies have uncovered the existence of functional amyloid fibers in unexpected domains, from bacteria to mammals.